The Use Of Theoretical Mechanistic Biochemistry (TMB) In The Rationalization Of The Experimental Data On Sacoglottis Gabonensis On The Natural Antioxidant Defense During 2,4-Dinitrophenyl Hydrazine Administration In-Vivo

Abstract

Sacoglottis gabonensis stem bark, a Nigerian alcoholic beverage additive has stimulated interest as an antioxidant (Ekong and Ejike, 1974; Madusoluomu, 1993; Okechukwu, 1998 and Maduka and Okoye 2002). Based on the structure of bergenin (Fig. 1), this study will present the use of Theoretical Mechanistic Biochemistry (TMB) (Akintonwa, 1986, Akintowa, 1995; Akintonwa, and Odigwe 2000; Akintonwa 2000, Akintonwa, 2001, Akintonwa, 2002) to rationalize the antioxidant propensity of bergenin on 2,4 dinitrophenylhydrazine, alcohol dehydrogenase and superoxide dismutase (SOD).