Abstract
Androgens affect skin by causing increases in vascularity, in content of oxyhemoglobin, and in rate of blood flow. They also bring about an increase in pigmentation due to augmentation of melanogenesis and supply of hemoglobin; as well as stimulation of sebaceous glands and changes in texture related to salt, water and nitrogen retention. Various observers have noted these effects in experimental animals (1, 2, 3, 4), and also in man (5, 6, 7). There are, however, only scattered observations concerning the clinical use of these compounds in specific skin diseases (8, 9, 10). One of the present authors (B. B. W.) had previously noted striking changes in the skin of patients with carcinoma of the breast who were receiving testosterone therapy (11).
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