Abstract
Implantation of crystalline sulfanilamide in the peritoneal cavity has been practiced by many surgeons during the past year. Local application of sulfanilamide and its derivatives has been a valuable method of utilizing these drugs. In 1939 Jensen, Johnsrud and Nelson 1 reported the implantation of sulfanilamide in compound fractures with a considerable reduction in the usual incidence of infection. Burns, chronic ulcers, infected wounds, mastoid cavities, the lesions of acute and chronic osteomyelitis, meningeal abscesses and infected pleural cavities all have been treated with topical chemotherapy. When sulfanilamide first came into use it was felt to be effective primarily against infections with hemolytic streptococci. With sulfanilamide treatment, a reduction in mortality due to primary streptococcic peritonitis was reported. 2 In peritonitis associated with appendicitis the infection is often a mixed one, with colon bacilli, Welch bacilli and various strains of streptococci commonly participating; 3 yet Ravdin, Rhoads and Lockwood 4
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