Abstract
HANZLICK et al. (1939) showed that propylene glycol could replace some of the carbohydrate in diets for dogs. At low levels there were no ill effects on the dogs and the addition of propylene glycol caused an increase in the levels of blood sugar. When higher levels of propylene glycol were used some was lost in the urine.Rudney (1950) showed that propylene glycol is converted to lactic acid and hence to glucose in the rat. Miller et al. (1953) proposed a metabolic pathway for the conversion of phosphorylated propylene glycol to lactic acid with the generation of a high energy phosphate bond and the reduction of two moles of NAD. Maplesden (1954) described the use of propylene glycol in the treatment of ketosis in dairy cattle. Increasing amounts of this material are being made available and with a gross energy value of 5650 Kcal./kg. as compared with 4000 Kcal./kg… .
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