Abstract
Background: Acute pancreatitis (AP) is an inflammation of the pancreas, a serious emergency with no definitive treatment. It may progress to infected necrosis, non-pancreatitis infection, also death that may occur within the first 1 to 2 weeks. The use of prophylactic antibiotics in AP to prevent complications remains a controversy. The objective of this meta-analysis is to assess the benefit of prophylaxis antibiotics administration to prevent the complication.Method: Trials were identified by searching the medical database. Literature range is within the year 1975 to 2021. Review Manager 5.4.1 was used to analyse data extraction and risk of bias of included studies were elaborated. Risk ratio (RR) was calculated with 95% confidence interval (CI). P 0.05 was considered significant.Results: Twenty trials with a total of 1.287 patients of AP were analysed; 646 patients treated with antibiotic prophylaxis and 641 patients treated with placebo. Prophylaxis antibiotics were found to have significant difference between the two groups. The administration of prophylaxis antibiotics lower the risk of non-pancreatic infections (RR = 0.77; 95% CI: 0.62–0.95; p 0.05) and infected pancreatic necrosis (RR = 0.74; 95% CI: 0.58-0.94; p 0.05). Meanwhile, prophylaxis antibiotics were found to be insignificant to lower the risk of mortality (RR = 0.75; 95% CI: 0.54-1.03; p 0.05). Conclusion: Prophylaxis antibiotics lower the risk of non-pancreatic infections and infected pancreatic necrosis, but did not lower the risk of mortality.
Highlights
6,7 with a diagnosis of severe acute pancreatitis with clinical diagnosis (scoring system or criteria), as well as Within 72 hours of acute pain antibiotics as prophylaxis once acute pancreatitis is diagnosed, because after the necrosis phase is the the initial attack, so it is preferable to give prophylactic
1,4 search is limited to human studies and published in the beginning of newly diagnosed pancreatitis occurs were “acute pancreatitis,” “antibiotic prophylaxis,”
The results of data analysis showed that prophylactic administration of antibiotics in patients with acute pancreatitis can reduce the risk of non-pancreatic infections and infected pancreatic necrosis, but not prophylactic antibiotics in cases of Acute pancreatitis (AP) can reduce
Summary
6,7 with a diagnosis of severe acute pancreatitis with clinical diagnosis (scoring system or criteria), as well as Within 72 hours of acute pain antibiotics as prophylaxis once acute pancreatitis is diagnosed, because after the necrosis phase is the the initial attack, so it is preferable to give prophylactic Studies within this range of scores are considered administering antibiotics as prophylaxis in preventing the occurrence of infected pancreatic necrosis, nonconsidered of poor quality, so it is not included in the included had a low risk of bias
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