Abstract
Background: There has been tremendous improvement in the knowledge of prophylactic antibiotics use in surgery. There are controversies on the use of prophylactic antibiotics clean surgical cases. This study aims to determine if there is need to use prophylactic cefuroxime in day case herniotomy at the Abia State University Teaching Hospital Aba. Objective: To determine if there is need for prophylactic antibiotics in paediatric day case herniotomy and to compare the rate of surgical site infection in patients that receive preoperative cefuroxime to patients that did not receive it. Method: This was a hospital based prospective study carried out between April 2017 and April 2018 during which 126 herniotomy were performed as day cases at the Abia State University Teaching Hospital Aba. The patients were randomly placed into two groups: 63 patients in group A that received prophylactic cefuroxime at induction of anaesthesia and 63 patients in group B that did not receive cefuroxime. The two groups were compared to determine the factors that influenced development of surgical site infection. Results: There were 115(91.3%) males and 11(9.7%} females. Their ages ranged from 1-14 years with a median of 2 years. The average duration of the operative procedure was 34.8 minutes (34.3 minutes in group A and 35.4 minutes in group B). After a follow up of 3 weeks, a total of 8 patients developed surgical site infection (3 patients in group A; 5 patients in group B) (p=0.358). The duration of operation (p= 0.549) and mode of transport (p=0.605) did not affect rate of surgical site infection. Conclusion: Development of surgical site infection after day case herniotomy in our hospital is not affected by the use of prophylactic antibiotics and duration of operation. The study confirms that day case herniotomy can be undertaken without prophylactic antibiotics.
Highlights
Surgical antimicrobial prophylaxis refers to the use of antimicrobial agent administered prior to an operation, its function is to reduce the burden of contamination from endogenous flora of patient’s skin and exogenous sources of surgical site infection like surgical personnel, operating room environment, instrument and materials brought to the sterile field to a level manageable by host defenses[1]
The inappropriate use of prophylactic antibiotics in terms of the wrong choice of antibiotics, dosing, timing, duration and Advances in Surgical Sciences 2018; 6(1): 36-40 sensitivity to prevailing micro-organisms has been shown to increase antibiotics resistance and it is associated with poor clinical outcome. [11,12,13,14,15]
This study showed that the difference between the rates of surgical site infection in the two groups studied was not statistically significant
Summary
Surgical antimicrobial prophylaxis refers to the use of antimicrobial agent administered prior to an operation, its function is to reduce the burden of contamination from endogenous flora of patient’s skin and exogenous sources of surgical site infection like surgical personnel, operating room environment, instrument and materials brought to the sterile field to a level manageable by host defenses[1]. This study aims to determine if there is need to use prophylactic cefuroxime in day case herniotomy at the Abia State University Teaching Hospital Aba. Objective: To determine if there is need for prophylactic antibiotics in paediatric day case herniotomy and to compare the rate of surgical site infection in patients that receive preoperative cefuroxime to patients that did not receive it. Method: This was a hospital based prospective study carried out between April 2017 and April 2018 during which 126 herniotomy were performed as day cases at the Abia State University Teaching Hospital Aba. The patients were randomly placed into two groups: 63 patients in group A that received prophylactic cefuroxime at induction of anaesthesia and 63 patients in group B that did not receive cefuroxime. Conclusion: Development of surgical site infection after day case herniotomy in our hospital is not affected by the use of prophylactic antibiotics and duration of operation. The study confirms that day case herniotomy can be undertaken without prophylactic antibiotics
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