Abstract
The use of platelet-rich fibrin (PRF), a second-generation platelet concentrate, has gained popularity in the field of oral regenerative surgery. This review presents data from published clinical trials on outcomes from PRF application in regeneration of infrabony defects, implant site development, and mucogingival surgery. When PRF is used for regeneration of infrabony defects, minor improvements are noted in the clinical parameters that in the majority of the cases does not reach the level of statistical significance. The use of PRF appears to limit the dimensional changes of the alveolar ridge after tooth extraction when compared with sockets that are allowed to heal with no grafting. When combined with coronally advanced flaps (CAF) for root coverage, PRF shows a slight advantage over CAF alone. Despite the adequate volume of publications in the field, the limitations of the existing studies highlight the need for high level of evidence to support the significant benefit of PRF in hard and soft tissue within the scope of periodontal and peri-implant surgery.
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