Abstract

Kumanan Wilson and colleagues explain how the rapid response to XMRV as a novel pathogen has highlighted some challenges pertaining to policy-making and editorial responsibilities. The impact on policy and the propagation of the initial scientific information may not cease if the evidence is disproven and retracted from the peer-reviewed literature, which creates a challenge for regulators and scientific journals. Please see later in the article for the Editors' Summary.

Highlights

  • N The impact on policy and the propagation of the initial scientific information may not cease if the evidence is disproven and retracted from peer-reviewed journals

  • After months of scientific investigation into possible transfusion transmissibility and the potential links to both chronic fatigue syndrome (CFS) and prostate cancer, a consensus emerged that xenotropic murine leukaemia virus-related virus (XMRV) was a laboratory artifact, and not a threat to blood recipients [6]

  • Despite a thorough evaluation of risk and a series of publications discrediting the threat of XMRV, donor deferral policies still exist that target individuals with any past or present diagnosis of CFS

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Summary

Policy Forum

The Use of Preliminary Scientific Evidence in Public Health: A Case Study of XMRV. The xenotropic murine leukaemia virus-related virus (XMRV) controversy has made evident novel challenges related to integrating scientific evidence into policy making that concerns the safety of blood products and public health in general. The XMRV saga highlights new dilemmas pertaining to the publication of preliminary scientific evidence in matters of public health concern. These challenges have been created by the current precautionary policy-making paradigm, and the impact of the Internet and social media as a mechanism for the rapid transmission of health information. Concern over the threat of XMRV escalated in 2009 when a Policy Forum articles provide a platform for health policy makers from around the world to discuss the challenges and opportunities in improving health care to their constituencies

Summary Points
Blood Donor Policies
Permanent for any history of diagnosis of CFS
Findings
Conclusion
Full Text
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