Abstract
Perampanel (PER) is an antiepileptic drug (AED), the effects of which on sleep have not been studied in Russia.Objective: to assess changes in the quality of sleep, the level of daytime sleepiness, and the polysomnographic (PSG) characteristics of nocturnal sleep in patients with drug-resistant focal epilepsy when PER is incorporated into the therapy regimen as an additional AED.Patients and methods. The investigation enrolled 12 patients (4 men and 8 women) aged 21 to 49 years with drug-resistant epilepsy treated with several AEDs, who had initiated therapy with PER as an additional AED. PSG study and questioning survey were done before and 1 month after initiation of PER therapy.Results and discussion. After one month of PER therapy, there was an increase in the quality of night sleep in 5 cases and a reduction in daytime sleepiness in 6 cases. The PSG pattern was stable in 3 patients, worsened in 1, and improved in 8.Conclusion. The preliminary results suggest that PER therapy improves night sleep quality and reduces daytime sleepiness in about half of the cases, as evidenced by the improved PSG pattern in 67% of patients.
Highlights
Перампанел (ПЕР) – противоэпилептический препарат (ПЭП), исследований влияния которого на сон в России не проводилось
Perampanel (PER) is an antiepileptic drug (AED), the effects of which on sleep have not been studied in Russia
Objective: to assess changes in the quality of sleep, the level of daytime sleepiness, and the polysomnographic (PSG) characteristics of nocturnal sleep in patients with drug-resistant focal epilepsy when PER is incorporated into the therapy regimen as an additional AED
Summary
Применение перампанела при фокальной фармакорезистентной эпилепсии: влияние на сон. Филин А.А.1, Тардов М.В.1, Кунельская Н.Л.1, 2, Власов П.Н.3 1ГБУЗ «Научно-исследовательский клинический институт оториноларингологии им. Пирогова» Минздрава России, Москва; 3кафедра нервных болезней ФГБОУ ВО «Московский государственный медико-стоматологический университет им. Цель исследования – оценить изменения качества сна, уровня дневной сонливости и полисомнографических (ПСГ) характеристик ночного сна у пациентов с фармакорезистентной фокальной эпилепсией при включении ПЕР в схему терапии в качестве дополнительного ПЭП. Предварительные результаты свидетельствуют, что терапия ПЕР приблизительно в половине случаев улучшает качество ночного сна и снижает дневную сонливость, что подтверждается улучшением структуры ПСГ у 67% пациентов. Perampanel (PER) is an antiepileptic drug (AED), the effects of which on sleep have not been studied in Russia. Objective: to assess changes in the quality of sleep, the level of daytime sleepiness, and the polysomnographic (PSG) characteristics of nocturnal sleep in patients with drug-resistant focal epilepsy when PER is incorporated into the therapy regimen as an additional AED. The PSG pattern was stable in 3 patients, worsened in 1, and improved in
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