The Use of Oxygen in the Delivery Room.

Abstract

* Abbreviations: ci — : confidence interval GRADE — : Grading of Recommendations Assessment, Development and Evaluation ILCOR — : International Liaison Committee on Resuscitation PICO — : population, intervention, comparator, and outcome RCT — : randomized controlled trial We hope to base our practice on the best evidence available. The International Liaison Committee on Resuscitation (ILCOR) is committed to a transparent process that allows its guideline developers as well as the subsequent guideline users to understand how the evidence base was created and how the evidence is valued. In 2015, the ILCOR adopted a process that would enable a near continuous review of resuscitation science by evaluating high-priority population, intervention, comparator, and outcome (PICO) questions.1 The process is ambitious. Knowledge synthesis units with expertise in searching scientific databases and performing systematic reviews and meta-analysis address broad PICO questions (questions that may be large and complicated or topics covering several PICO questions that can be grouped together and explored by using sensitivity or subgroup analyses). Potentially, such a systematic review will lead to a meta-analysis and a broader understanding of the available evidence. Importantly, the ILCOR has endorsed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach.2 … Address correspondence to Roger F. Soll, MD, Neonatal-Perinatal Medicine Division, University of Vermont Medical Center, Smith 551, 111 Colchester Ave, Burlington, VT 05401. E-mail: roger.soll{at}uvmhealth.org