The Use of Oral Antidiabetics in Heart Failure: A Promising Therapeutic Approach

Abstract

This article examines the use of oral antidiabetic agents in the treatment of heart failure. Heart failure is a serious condition that is often associated with diabetes mellitus, which worsens the prognosis for patients. Oral antidiabetic agents, such as SGLT2 inhibitors and GLP-1 receptor agonists, have recently gained increasing interest due to their potential beneficial effects on cardiac function. Clinical studies have shown that these medications reduce cardiovascular morbidity and mortality, decrease hospitalizations for heart failure, and improve cardiac function in patients with heart failure, whether they are diabetic or not. The mechanisms of action of these medications include blood pressure reduction, improvement in endothelial function, modulation of cardiac energy metabolism, and reduction of oxidative stress and inflammation. While these findings are promising, further research is needed to better understand the long-term effectiveness and optimization of the use of these medications in the context of heart failure.