Abstract
In certain procedures it is desirable to inject neutral suspensions of the sulfonamides through fine hypodermic needles. Usually this is not possible with suspensions of the drugs currently available because of the large size and irregular shapes of the crystals. Dr. B. F. Souders and Dr. S. Brand Rose independently suggested that the crystals might be comminuted by sonic vibration. Direct vibration of suspensions of the preformed crystals produced no measurable effect, but an indirect procedure involving sonic agitation has been developed which reduces the crystal size sufficiently to permit passage through 26 gage needles. Essentially, the preparation of the microcrystalline sulfonamides consists in the neutralization, at low temperature, of a solution of a sodium salt of the drug, the reacting mixture being kept in violent agitation by sonic vibration or by some suitable high speed mixing device. The size of the resulting crystals may be regulated within wide limits
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