The use of manganese-doped mesoporous silica nanopowder for targeted drug delivery

O A Zlygosteva,S Yu Sokovnin,V G Ilves

doi:10.1088/1742-6596/1115/4/042067

Abstract

The researched manganese-doped mesoporous silica nanopowder (SiO2-MnO2 NP) was produced using evaporation caused by a pulsed electron beam in a vacuum. The synthesized material demonstrated high porosity, amorphous structure and magnetic properties increased with the addition of dopant. The evaluation of the sedimentation stability of NP suspensions showed the need for the additional stabilization. It was established that increasing the sonication time, as the way to increase stability, leads to changes in the structure of the NP. PEG stabilized suspensions showed the highest stability. Experimental results indicated that for different drugs individual methods of loading and release are required. Drug loaded NP demonstrated a high drug loading capacity of 0.09 mg Amoxicillin per mg NP, 0.075 mg Doxorubicin per mg NP that is five times higher than loading capacity of chemically synthesized NP.

Highlights

Nowadays, the interest in the use of NP for drug delivery has emerged and is significantly increasing.Conventional drugs frequently exhibit high toxicity in healthy tissues due to their nonspecific distribution and premature degradation
We investigated the ways to increase the stability of NP suspensions by selecting the optimal stabilizer and the method of sonication
Conclusion the researched SiO2-MnO2 NP obtained by the method of evaporation by a pulsed electron beam demonstrated the potential for its use as a drug delivery system with the following conclusions: 1. The SiO2-MnO2 NP has a high porosity in comparison with the MCM-41 NP produced by the chemical method with a significantly higher specific surface area

Summary

Introduction

The interest in the use of NP for drug delivery has emerged and is significantly increasing.Conventional drugs frequently exhibit high toxicity in healthy tissues due to their nonspecific distribution and premature degradation. Considering that the specific surface area (SBET) of NP and porosity affects the effectiveness of drug loading and release, the influence of the sonication time on the texture properties of SiO2 and SiO2-MnO2 NPs was studied. It was important to develop the effective method for drug loading and release from the SiO2-MnO2 NP structure.

Results

Conclusion