Abstract
After getting approval from IRB 15 patients were treated with the vaccine prepared from their own malignant serosal fluid. This study was done 1990. These were patients who had all conventional chemotherapy and have failed and had progressive disease. The serosal fluid was heat treated under aseptic condition so as to maintain the antigenecity but to lose the virulence of the malignant cells. The fluid then was injected subcutaneously half cc QOD first week and twice week second week and then once week. The patients were informed to report any unusual symptoms such as fever, rash or swelling at the injection site or any systemic effects. The patients were examined every month by the physician and the appropriate radiological work up was done every three months or earlier if needed. All the laboratory work was done to begin with and every fourth week.
Highlights
After getting approval from IRB 15 patients were treated with the vaccine prepared from their own malignant serosal fluid
The serosal fluid was heat treated under aseptic condition so as to maintain the antigenecity but to lose the virulence of the malignant cells
Besides the patient who had CR had gastric cancer and as we know the cancer genomics is more unique in gastric cancers such personalized therapy may be more specific in gastric cancer
Summary
After getting approval from IRB 15 patients were treated with the vaccine prepared from their own malignant serosal fluid. These were patients who had all conventional chemotherapy and have failed and had progressive disease. The serosal fluid was heat treated under aseptic condition so as to maintain the antigenecity but to lose the virulence of the malignant cells. The patients were informed to report any unusual symptoms such as fever, rash or swelling at the injection site or any systemic effects. The patients were examined every month by the physician and the appropriate radiological work up was done every three months or earlier if needed. The study on the fluid was limited as the technology was not advanced . We can determine Exons, cytokines or genetic analysis, microRNAs
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