Abstract
Introduction: Alcohol consumption, specifically heavy drinking during adolescence, has been shown to be accompanied by adverse structural brain changes in adolescent drinkers. This scoping review will aim to quantify and evaluate the quality of studies in which magnetic resonance imaging (MRI) techniques are used to assess regional brain deficits among adolescents who consume alcohol. Methods and analysis: This scoping review will be conducted following the Arksey and O’Malley scoping review methodology framework and will be reported using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) extension for Scoping Reviews (PRISMA-ScR) guidelines. Literature will be searched for the period January 1999 to March 2021. Two reviewers will independently screen titles/abstracts and full-texts in two consecutive screening stages. Eligible studies will be independently reviewed to ensure that inclusion criteria are met. Cohen’s Kappa (κ) will be used to calculate inter-rater agreement. A third reviewer will resolve any disagreements. The Joanna Briggs Institute (JBI) Appraisal Tools will be used for quality appraisal of the included studies. Findings will be reported by means of a narrative overview, tabular presentation of study characteristics, and quality assessment, and a thematic analysis of major themes. This scoping review has been registered with the Open Science Framework. Ethics and dissemination: Scoping reviews do not require ethical approval, however, this review forms part of a larger study that has obtained approval from the Faculty of Health and Medical Sciences, Health Research Ethics Committee at Stellenbosch University (S20/04/086). Findings will be disseminated by means of peer-reviewed publications and conferences.
Highlights
Alcohol consumption, heavy drinking during adolescence, has been shown to be accompanied by adverse structural brain changes in adolescent drinkers
Strengths and Limitations of This Study. This scoping review provides a critical review of the magnetic resonance imaging (MRI) techniques in identifying neuroanatomical brain deficits associated with adolescent alcohol consumption
The aim of this systematic scoping review is to identify the quantity and evaluate the quality of studies examining brain magnetic resonance imaging (MRI) studies investigating neuroanatomical deficits associated with adolescent alcohol consumption including heavy episodic drinking (HED)
Summary
This scoping review provides a critical review of the MRI techniques in identifying neuroanatomical brain deficits associated with adolescent alcohol consumption. In addition to the mapping of the evidence, this scoping review will provide a critical appraisal of the evidence using appropriate Joanna Briggs Appraisal Tools. A comprehensive search strategy was developed with the assistance of an information specialist and a public health systematic review expert. The technical aspects of the methodology was guided by the public health systematic review expert. The team consisted of experts in addiction research, neuroimaging techniques, and public health systematic reviews. This scoping review was registered with the Open Science Framework This scoping review was registered with the Open Science Framework (https://osf. io/n5xud/ accessed on: 20 March 2020)
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