Abstract
Journal of Cancer Metastasis and Treatment is an open access journal, focusing on basic and clinical studies related to cancer cell, cell biology, oncology, radiation therapy and radiology, obstetrics and gynecology, pediatrics, surgery, hematology, neuro-oncology, etc.
Highlights
About 276,480 new cases of invasive breast cancer will be diagnosed among American women within 2020[1]
Taking in consideration the clinical evidence produced in the following years, partly due to the deployment of new technologies, here we address the potential prognostic or predictive role of circulating tumor DNA (ctDNA) detection before any primary treatment and the possible implications
With high specificity (100%) but very low sensibility (31%), the patients identified by ctDNA detection had a significantly inferior disease-free survival (DFS) if compared with relapsed patients and negative ctDNA (P < 0.0001, median DFS: 4.6 months. vs. Not Reached (NR); hazard ratio (HR) = 12.6, 95%confidence interval (CI): 3.06-52.2)
Summary
About 276,480 new cases of invasive breast cancer will be diagnosed among American women within 2020[1]. This incidence means breast cancer is the second most common cancer, showing a slightly increasing trend in recent years (by 0.3% per year). Only 27% of patients with metastatic breast cancer (mBC) will reach the 5th year after diagnosis[3]. In consideration of these data, it is fundamental that efforts are made to ensure that diagnosis of both primary and potential recurrence is made as early as possible
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