Abstract
In this introductory lecture of the Symposium, essential knowledge concerning biological mechanisms of post highradiation dose will be present. Emerging evidence suggests that distinct mechanisms of cell death, likely including a major contribution from vascular epithelial cell apoptosis (devascularizing effect), might play an important role in the success of SBRT in controlling tumors. Also “5Rs” of conventional fractionated RT will be discussed in aspect of SBRT, including new pathways of tumor clonogen repopulation, i.e. “phoenix rising”, as well as constructing SBRT cell survival curve attempts. However, studies taken toward maximizing this effect should also be designed with the cautionary awareness that tissue regenerative processes might also be triggered as a result.
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