Abstract
Medication-related osteonecrosis of the jaw (MRONJ) is the bone necrosis of the jaws and can be associated with antiresorptive or antiangiogenic therapy. A 79-year-old female patient with history of ovarian cancer received 14 doses of bevacizumab. The maxillary total prosthesis caused 2 lesions with painful symptoms, and purulent drainage in the oral and nasal cavity. CBCT shows kidnapping and bone lysis staged as MRONJ 3 in the hard palate and 2 in the alveolar ridge. Both lesions were removed of all necrotic bone beside an amalgam tattoo in the bone tissue of the alveolar ridge and joined the L-PRF primary closure of the wound. Six months after surgery, the patient had complete healing confirmed by CBCT. The L-PRF association with the surgical procedure is suggested to be a good alternative in the treatment of MRONJ. This should spark a discussion to define the role of amalgam tattoo as an additional factor in the case of MRONJ.
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