THE USE OF KETOPROFEN NIOSOMES FOR FORMULATION OF SUSTAINED RELEASE TABLET DOSAGE FORM

Mohamed Raslan

doi:10.21608/ajps.2012.7119

Abstract

The objective of this study was to formulate sustained release tablet dosage form (100 mg) using Ketoprofen Niosomes. Ketoprofen Niosomes were prepared by lipid hydration method and then dried and compressed into sustained release tablets (100 mg). The tablet excipients employed include: Avicel PH 101, Avicel PH 102, and Mannitol as diluents, Cab-O-Sil (colloidal silica) as a glidant, Starch as a disintegrant and Magnesium Stearate as lubricating agent. The tablets were tested for weight variation, hardness, friability, thickness, disintegration, drug content and release ratio. Finally the release kinetics of Ketoprofen tablets were calculated.

Highlights

Development of oral sustained release drug delivery systems is of much interest to the pharmaceutical scientists as these systems provide prolonged duration of action of drugs having short biological half-life, and reduce dose-related toxicity, dosing frequency, and patient non-compliance (Chien, 1997; Uhrich et al, 1999)
Various drug delivery techniques have been developed to sustain the release of drugs; recently colloidal particulate carriers such as Niosomes have been employed in drug delivery systems (Shahiwala and Misra, 2002)
Due to their capability to carry a variety of drugs, Niosomes has been extensively used in various drug delivery systems like controlled release (Gupta et al, 2005; Puglia et al, 2004)

Summary

Introduction

Development of oral sustained release drug delivery systems is of much interest to the pharmaceutical scientists as these systems provide prolonged duration of action of drugs having short biological half-life, and reduce dose-related toxicity, dosing frequency, and patient non-compliance (Chien, 1997; Uhrich et al, 1999). Various drug delivery techniques have been developed to sustain the release of drugs; recently colloidal particulate carriers such as Niosomes have been employed in drug delivery systems (Shahiwala and Misra, 2002). Due to their capability to carry a variety of drugs, Niosomes has been extensively used in various drug delivery systems like controlled release (Gupta et al, 2005; Puglia et al, 2004). Ketoprofen has some disadvantages as the short half-life, low bioavailability and disturbance in the GI tract, so formulation of controlled release dosage forms is needed (Palmieri et al, 2002)

Objectives

Methods

Results