Abstract
IgG plays multiple roles in the immune system. Best known as an effector molecule in host defence, infusions of polyclonal IgG have been employed as the mainstay of treatment for patients with immunodeficiency diseases affecting the humoral immune system. IgG preparations are fractionated from pools of several hundred to several thousand donors or more and therefore contain a broad spectrum of antibodies, capable of providing protection against many bacterial and viral diseases. Preparations of human IgG are available for intravenous (IVIG) or subcutaneous (SCIG) administration, allowing individuals with both primary and secondary immune defects to have significantly fewer infections, decreased hospitalizations and overall improved quality of life (QOL). Moreover, IVIG has been employed as a regulator of a large number of autoimmune and inflammatory conditions since the 1980s.
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