Abstract
Publisher Summary This chapter discusses the effects and mechanism of action of molecules that upon incorporation into model and biological lipid bilayers increase the permeability of the membrane to ions. As the molecules act similarly in biological and synthetic lipid membranes, it is assumed that these compounds operate in the lipid milieu of the membrane. The biological membranes are a fluid mosaic composed of lipids arranged in a bilayer in which proteins either go across the lipid phase or are partially submerged in the membrane. The membranes formed exclusively with lipids are highly impermeable to ions and the impermeability is determined by the existence of the lipid bilayer. Compounds that lower ion permeability have been used to explore the properties and structure of biological membranes. The ATP synthesis can be driven by a proton-motive force of sufficient magnitude
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