The use of ionisation constants of amino acids for protein signal analysis within the resonant recognition model--application to proteases

Abstract

Biological functions of proteins and their active 3D structures are determined by the linear sequences of amino acids. The resonant recognition model (RRM) is a physico-mathematical model developed for structure/function analysis of protein and DNA sequences. Here, we are comparing results of the RRM analysis [1,2] of protease proteins using the electron-ion interaction potential (EIIP) and ionisation constant (IC) of amino acids. The results obtained reveal that the IC parameter can be successfully used to determine the characteristic patterns of different functional protease subgroups.