Abstract
Various modalities have been used extensively in the treatment of malignant skin neoplasms, usually with considerable success. Clinical situations arise, however, when lesions are so advanced on presentation that standard therapeutic measures are unlikely to achieve tumour eradication. This paper documents the use of intra-arterial infusion chemotherapy as basal treatment in eleven such patients–five with advanced squamous carcinoma of skin of face; four with extensive peripheral limb lesions (including two patients with Marjolin's ulcers): one patient with lymphoma of skin; and another with locally extensive malignant melanoma. In all cases, except the patient with melanoma, there was a major regression of the tumours sufficient to allow local tumour eradication with subsequent radiotherapy and/or surgery.
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