Abstract
NADEL and Eisenstark (1955) observed a stage in the development of Newcastle virus in chick embryos in which the allantoic fluids contained hemagglutination units but were devoid of infective power. The interpretation placed upon this observation was that Newcastle virus, in the maturation cycle, passes through an “incomplete” stage in which the virus possesses some of the properties of the mature form but lacks the property of infectivity. This phenomenon suggests the “incomplete” stage in the maturation of influenza virus reported by numerous investigators (von Magnus, 1953; and Henle, 1953).Von Magnus (1951) demonstrated that the “incomplete” PR-8 influenza virus possessed antigenic properties. Similarly Nadel (1955) showed that “incomplete” California strain 11914 Newcastle virus stimulated antibody production in rabbits, and that these antibodies gave a good hemagglutination-inhibition (HI) test (Cunningham, 1952) when checked against the mature virus form. This suggested the possibility that “incomplete” Newcastle virus might be effective as …
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