The Use of Hyperspectral Technology in a Cuff‐Ischemia Model

Abstract

Background: Hyperspectral technology has been developed to monitor tissue oxygenation status in order to predict healing or the need for arterial revascularization. We undertook a study to demonstrate the performance of hyperspectral technology oxygenation monitoring (HTOM) in the assessment of tissue oxygenation in a controlled low/no flow ischemia model in normal volunteers. Methods: Tissue oxygenation was measured in the lower & upper extremities of twelve normal volunteers at baseline, during no/low flow cuff ischemia, & during recovery. Tissue oxygenation was assessed by HTOM & transcutaneous oxygen partial pressure measurements (TcPO2). Results: Baseline pre-occlusion HTOM hemoglobin oxygen saturation values were 35±10% & 35±11% in the skin of the volar forearm & dorsal foot, respectively. These values decreased to 5±5% & 4±5% following total occlusion. These values demonstrated a reperfusion overshoot & then returned to baseline following release of the cuff. HTOM measurements showed consistently lower tissue hemoglobin oxygen saturation during ischemia compared to baseline & recovery states (p<.0001). Conclusions: Although ischemia measurements are made in extreme circumstances of complete arterial occlusion, this study successfully demonstrated a response to low/no flow ischemic conditions measured by HTOM in normal volunteers. It also demonstrated the hyperemic response to post-arterial occlusion revascularization.