Abstract
Background: Hyaluronidase can be employed to manage a variety of complications associated with cosmetic hyaluronic acid (HA) filler injection. However, the indications and treatment protocol for hyaluronidase use have not been well established.
Highlights
Hyaluronic acid (HA) filler injection is an increasingly popular technique utilized for volume replacement, noninvasive skin rejuvenation, and soft tissue augmentation
In one case reported by Brody and colleagues, a patient presented with soft nodules with blue discoloration after hyaluronic acid (HA) injection in the bilateral infraorbital area [10]
Hyaluronidase is an important tool in the management of complications related to HA filler injections
Summary
Hyaluronic acid (HA) filler injection is an increasingly popular technique utilized for volume replacement, noninvasive skin rejuvenation, and soft tissue augmentation. Kim et al reported a case series of four patients who developed skin necrosis after HA filler injection in the nasal area. Several cases have been reported in the literature that describe successful resolution of nasojugal and cheek nodules associated with HA injection after injection of 75 units of hyaluronidase, reconstituted in 0.5% lidocaine with epinephrine [25,26].
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