The use of high-density electrophysiology in the early detection of cognitive and language impairments in preterm infants.

Abstract

Event Abstract Back to Event The use of high-density electrophysiology in the early detection of cognitive and language impairments in preterm infants. Natacha Paquette1, 2*, Phetsamone Vannasing1, Michelle McKerral3, Franco Lepore1, 2, Maryse Lassonde1, 2 and Anne Gallagher1, 2 1 Sainte-Justine University Hospital Center , Research Center, Canada 2 University of Montreal, Psychology, Centre de Recherche en Neuropsychologie et Cognition, Canada 3 University of Montreal, Psychology, Canada The last months of pregnancy are particularly important for the development of the central nervous system and many intrauterine events occurring between 24 and 40 weeks of gestation are crucial for fetal development. Thus, many children born prematurely will show language and / or cognitive disorders at school age. This study aims to establish a protocol for screening for these disorders in premature and full term born infants using the Mismatch Negativity (MMN) and auditory evoked potentials (AEPs), associated with auditory preattentional processing. Using an oddball paradigm during EEG recording, 40 healthy participants (3-32 years of age) were first evaluated to document the normal maturational changes of the MMN in the verbal and non-verbal modalities. Eighty-two children (3, 12 and 36 months of age), born at term or prematurely, were subsequently evaluated using EEG and a neurodevelopmental assessment (Bayley-III) to identify electrophysiological predictors of cognitive and language impairments. Based on MMN and AEPs characteristics, results revealed a distinct development of verbal and nonverbal preattentional processes in healthy children. Age-related differences for non-speech discrimination occurred earlier in children's development than the discriminative process for speech sounds. Compared to full term infants, premature infants showed an atypical MMN at the ages of 3 and 12 months and a delayed P1 component at 12 months of age during the discrimination of verbal sounds exclusively. No significant difference was observed between preterm and full term infants when discriminating the non-speech stimuli. Moreover, preterm infants of all age groups scored significantly lower than full term children on the language and cognitive scales of the Bayley-III. These results may allow the early identification of language and cognitive impairments that may be encountered by premature birth. Keywords: Cognition, Language, mismatch negativity (MMN), Infant Development, Preterm Birth, neonatal brain injury, Auditory evoked potentials (AEPs) Conference: XII International Conference on Cognitive Neuroscience (ICON-XII), Brisbane, Queensland, Australia, 27 Jul - 31 Jul, 2014. Presentation Type: Poster Topic: Language Citation: Paquette N, Vannasing P, McKerral M, Lepore F, Lassonde M and Gallagher A (2015). The use of high-density electrophysiology in the early detection of cognitive and language impairments in preterm infants.. Conference Abstract: XII International Conference on Cognitive Neuroscience (ICON-XII). doi: 10.3389/conf.fnhum.2015.217.00289 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 19 Feb 2015; Published Online: 24 Apr 2015. * Correspondence: Mrs. Natacha Paquette, Sainte-Justine University Hospital Center, Research Center, Montreal, Canada, natacha.paquette@umontreal.ca Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Natacha Paquette Phetsamone Vannasing Michelle McKerral Franco Lepore Maryse Lassonde Anne Gallagher Google Natacha Paquette Phetsamone Vannasing Michelle McKerral Franco Lepore Maryse Lassonde Anne Gallagher Google Scholar Natacha Paquette Phetsamone Vannasing Michelle McKerral Franco Lepore Maryse Lassonde Anne Gallagher PubMed Natacha Paquette Phetsamone Vannasing Michelle McKerral Franco Lepore Maryse Lassonde Anne Gallagher Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.