Abstract
免疫检查点抑制剂(immune checkpoint inhibitors, ICIs)通过激活机体的肿瘤免疫杀灭肿瘤细胞,给肿瘤患者的治疗带来新的希望。然而也可引起一系列以免疫损伤为基础的免疫检查点抑制剂相关毒副反应(immune-related adverse events, irAEs)。糖皮质激素是治疗这类毒副反应的基础,而在具体治疗irAEs时,其用法、用量、疗程又与治疗经典的自身免疫性疾病有所不同。同时,大剂量的糖皮质激素的长期使用可能引起严重的不良反应,本文对激素的作用机制、剂量剂型、毒副作用及管理等方面进行详细描述,为肿瘤医生在临床实践中应用激素提供参考和建议。
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