Abstract
Gas phase analytical procedures have been developed for the direct study of phospholipids. Glycerophospholipids undergo thermal cleavage to yield diglycerides. The reaction apparently involves an ortho acid (ester) structure as an intermediate. The phosphate ester group was also eliminated from silylated sphingomyelins when these compounds were subjected to direct GLC analysis. The derivatives corresponded to dehydration products. Ceramides were investigated by GLC, because of their structural relationship to sphingomyelins. It was possible to obtain TMSi derivatives of ceramides which could be studied by GLC and GLC-MS methods. The mass spectra of the derivatives showed characteristic fragmentation patterns that permitted their identification in terms of specific structural relationships.
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