Abstract
SESSION TITLE: COPD 2 SESSION TYPE: Original Investigation Poster PRESENTED ON: Wednesday, November 1, 2017 at 01:30 PM - 02:30 PM PURPOSE: To study the values of FENO in COPD exacerbation, the relationship with disease stage and pulmonary function test and the use of FENO in differential diagnosis of COPD exacerbation and bronchial asthma METHODS: This was a prospective study. FFNO has been measured in 112 patients with COPD exacerbation, 98 male and 14 female, mean age 63 (±11.1) years and 122 patients with bronchial asthma. FENO was measured by an electrochemical nitric oxide analyzer (NIOX MINO; Aerocrine AB, Solna, Sweden), consistent with the ATS guidelines published in 2005. We used t test and ANOVA. Significance was defined as a p value of < 0.05. RESULTS: The mean of FENO in asthma and COPD was 41.4 ± 36,7 SD and 11.9 ppb ± 7.6 SD respectively. This difference is statistically significant (p <0.01). Among the 112 subjects with COPD the FENO values according to the severity of bronchial obstruction are: Small airways 13,8 ± 9,3 SD, Mild 11,8 ±6,1 SD, Moderate 11.5 ± 8 SD, Severe 11 ± 5,8 SD, Very severe 11,6 ± 7,7SD. CONCLUSIONS: There was no significant change between the mean of FENO to the degrees of bronchial obstruction of COPD exacerbation. There is no correlation between FENO values with the values of FEV1, FVC, FEV1/FVC, TLC, RV, RV/TLC, Raw, MEF 25, MEF 50, MEF 75 in COPD patients.On future it is important to know which are the FENO values after the treatment of COPD exacerbations. CLINICAL IMPLICATIONS: FENO is important biomarker in differential diagnosis of asthma with COPD exacerbation. DISCLOSURE: The following authors have nothing to disclose: Eugerta Dilka, Artan Simaku, Eritjan Tashi, Esmeralda Nushi, Dafina Todri, Alma Teferici, Oltion Sina, Serxho Golgota, Jetmira Shehu, Jeta Beli, Roland Kore, Perlat Kapisyzi No Product/Research Disclosure Information
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