Abstract
One hundred cases of squamous cell carcinoma in oral and maxillofacial regions, including 50 fresh samples and 50 paraffin-embedded blocks, were examined with the use of Flow-cytometry (FCM) for DNA content of tumour cells, changes in ploidy, and kinetics of tumour cells. The results showed that: the average DNA Index (DI) was 1.154; the incidence of heteroploidy was 59%; and the S-phase cell proportion (PI) was 22.62%. Following the advance of tumour, as assessed by clinical stage and pathological grade, the rate of heteroploidy, DI and PI increased markedly. The results demonstrate that FCM can be utilized as an adjunct method for pathologic diagnosis with particular importance in the evaluation of malignant grade of neoplasms.
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