THE USE OF EARLY EMBRYO AGGREGATION DERIVED MOUSE CHIMAERAS. II. THE STUDY OF DISEASE PROCESSES*

Abstract

Early embryo aggregation derived mouse chimeras have proven an extremely valuable tool to study development of disease processes. In this respect chimaeras prove a unique opportunity to study the interaction between cells genetically pre-destined to become diseased and a normal cell population within the same animal. In this situation chimaeras can be studied in view of possible 'correction' of the disease by the provision of a population of normal host cells and/or their products. Various host deficiency states including classic immune deficiency, potentially 'deficient' anemias and tumours have been studied--the subject of the review here.