Abstract
The use of dendrimers as a modern drug delivery platform
Highlights
The therapeutic potential of many active substances cannot be realized in clinical practice due to adverse physic–chemical properties, variable pharmacokinetics and a range of adverse effects causing low bioavailability and unsatisfactory therapeutic concentration in the target tissue
We did a research for characterization of dendrimers with encapsulated active substance and processing and comparison of clinical trial results on the efficacy and toxicity of drugs incorporated into dendrimers against different types of disease
Doxorubicin is used in the treatment of several types of cancers, but due to the adverse effects, several formulations of doxorubicin with dendrimers have been investigated, and the results have shown that P1 and P2 particles inhibit cancer growth twice as much, and that is result of the additive effect of complex of dendrimers with DOX, as well as a significant reduction in side effects (Zhang et al, 2018)
Summary
The therapeutic potential of many active substances cannot be realized in clinical practice due to adverse physic–chemical properties, variable pharmacokinetics and a range of adverse effects causing low bioavailability and unsatisfactory therapeutic concentration in the target tissue. The most common investigated and characterized nanosystems are dendrimers, as a new class of polymers. Dendrimers as nanosystems are formulated from materials that are biocompatible, biodegradable and non-immunogenic. They have unique properties like thermodynamic stability, small particle size (1-20 nm), low polydispersity index and negative zeta potential (Svanson et al, 2018). The dendrimer structure is compatible with a range of hydrophilic and hydrophobic active substances with high encapsulation efficiency using different preparation methods (Abasi et al, 2014)
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
