Abstract
THE EFFECT of androgens on mitotic activity in the seminal vesicle of the castrate rat or mouse was first used by Loewe and Voss1 for the assay of these substances.The test was considered positive if mitoses were found in the epithelium of the seminal vesicles of the castrate rodent 48 hours after injection of the substance: to be tested. This test has not been widely accepted as the finding of mitosis is not uniform. Even in rapidly growing organs the incidence of mitosis is not high. In an animal treated even with large doses of androgens mitoses may be found in some sec' tions of the seminal vesicles but not in others. Through the work of Dustin2 colchicine has become a valuable help in studying mitotic activity. This alkaloid arrests mitosis in metaphase. Mitotic figures in cells which divide during the period in which colchicine is active are accumulated.
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