Abstract
A simple and sensitive analytical method has been developed for the spectrophotometric assay of amlodipine besylate (ADB) in pure forms and tablets have been described. The method is based on the formation of a charge-transfer complex between the drug and tetrachloquinone (TCQ). This complex exhibit intense absorption bands in the electronic spectrum. The molecular ratio of the reactant in the complex was established and the experimental conditions leading to maximum charge-transfer band was also studied. The reaction proceeds quantitatively at pH 9 and 55°C for 10 min, the absorbance was measured at 346 nm. The method was applied to commercially available tablets and the results were statistically compared wrth those obtained by UV spectrophotometric method, using Newman-Keuls tests. In our method, Beer's Law limits to 5-25 µg/ml. The optimum experimental parameters for colour production with reagent were studied and incorporated into procedure.
Highlights
Amlodipine besylate (ADB) is a calcium channel blocking agent with vasodilatory activity similar to that of nifedipine[l] and it was recently introduced for the treatment of angina pectoris and hypertension [2,4]
Charge-transfer complex forming reactions used in the determination of electro-donating basic compounds through interaction with &acceptors [12-181or IT-acceptors [19-2I], offered sensitive, accurate and easy to carry out analytical methods
This paper reports a simple and sensitive spectrophotometric method for the ADB in tablets
Summary
Amlodipine besylate (ADB) is a calcium channel blocking agent with vasodilatory activity similar to that of nifedipine[l] and it was recently introduced for the treatment of angina pectoris and hypertension [2,4]. The charge-transfer complexes with amlodipine had not been occurred in these methods which reported. Charge-transfer complex forming reactions used in the determination of electro-donating basic compounds through interaction with &acceptors [12-181or IT-acceptors [19-2I], offered sensitive, accurate and easy to carry out analytical methods. The method involves the formation of a charge-transfer complex (CTC) between the drug and chloranil (TCQ)
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