Abstract
Twenty-one infants and children received combined intramuscular penicillin and oral caronamide therapy for periods ranging up to 8 weeks. Marked increases in the maximal and minimal serum penicillin levels were regularly obtained when caronamide was given in a daily dosage of from 0.4 to 0.8 gm./kg. body weight. No relation was observed between the height of serum caronamide levels and serum penicillin levels. Caronamide was found to inhibit reversibly the tubular excretion of phenol red. No serious toxic effects of the drug were observed. Several successfully treated patients are described briefly, and a suggestion is made as to the type of pediatric case in which the use of caronamide is indicated.
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