Abstract
This study concerns the reduction of edema in heart failure especially in those patients in whom the effort to increase the amount of diuresis by digitalis, theocin and diuretin fails. Blum1 and his coworkers have made efforts in this direction, using calcium chloride as an agent and giving it by mouth. Singer,2 basing his observations on Loewi's experiments, reported striking successes by giving calcium chloride and digitalis together intravenously. It may be recalled that Loewi3 believes he has shown that calcium and digitalis have identical effects, the function of digitalis being merely to sensitize the heart muscle to the action of calcium. In one patient whom we have observed over a long period of time digitalis, theocin and diuretin produced a diuresis but not to the extent of freeing the patient of edema. She was, on the other hand, on repeated occasions made edema free by using calcium chloride. We did not make studies to determine the mechanism by which this diuresis was brought about. The resul...
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