Abstract

Nineteen patients with unspecific non-puerperal mastitis were treated exclusively by bromocriptine (BC) without administration of antibiotics. The analysis of breast symptomatology revealed that each patient exhibited benign breast disease. Four patients suffered from mastodynia, two of them were in puberty and two were taking oral contraceptives. In eight non-pregnant and two pregnant patients inappropriate lactation constantly or temporarily was present. One of them had a milk duct fistula. In four patients plasma-cell mastitis was diagnosed. One patient developed macromastia during pregnancy. The patients were treated initially with 7.5 mg BC/day for 3 days followed by 5 mg BC/day for a further 11 days. Five patients with inappropriate lactation developed small subcutaneous abscesses, which perforated spontaneously. In all other cases inflammation disappeared without complications. Non of the patients exhibited malignancy criteria. Over a period of 4 months following the acute treatment the patients were controlled without medical treatment. During this period in 12 patients inflammation recurrence occurred. Therefore each patient except the pregnant patients received a prophylactic course of 2.5 mg BC daily for 6 months in order to prevent recurrence of the disease. During BC prophylaxis no recurrence was observed except in the patient with a milk duct fistula. This patient recovered completely after excision of the fistula. During prolactin inhibition by BC alveolar secretion ceased and hormonally induced morphological changes of the mammary gland normalized which obviously had facilitated breast inflammation. In this way bromocriptine is of benefit in the treatment of non-puerperal mastitis and an adequate prophylaxis against inflammation recurrence.

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