The use of Biobrane® for wound coverage in Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis

Abstract

IntroductionPublished experience describing the use of Biobrane® for wound management in Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis (SJS–TEN) is limited to case reports and case series involving ten or fewer patients. We have used Biobrane® in the care of SJS–TEN since 2000, and the purpose of this study was to review our experience with the application of Biobrane® for wound coverage in SJS–TEN. MethodsA retrospective review of all cases of SJS–TEN admitted to an adult regional ABA-verified burn center between January 1, 2000 and June 1, 2015 was conducted. Biobrane® application was performed at burn center admission. Values are presented as the median (IQR), or mean±SD where appropriate. ResultsWe identified 42 eligible subjects with SJS–TEN. Biobrane® was applied in 24 subjects. Biobrane®-treated subjects had an age of 51.4±21.7years, with a %TBSA epidermal detachment of 39.5 (30–46), 63% were female and the admission SCORTEN was 3 (2–4, range 1–5). Biobrane® was applied at burn center (BC) admission in 18/24 subjects (82%), and between post admission days 1–4 in four subjects. Biobrane® was applied to 35 (22–40) % of the TBSA (range 7–90) involving all anatomic areas including the head and neck. There were no complications, infections, premature removals, or Biobrane®-associated sepsis in 24/25 applications (96%). In one subject a sheet of the TBSS was removed due to sub-Biobrane® fluid collection, but with negative microbiological cultures. Time to healing was 13 (12–16) days, and burn center length of stay was 34 (15.3–62.3) days. Subjects treated with dressings only (n=18) had a significantly smaller %TBSA epidermal detachment [10 (5–22), p<0.001], and were predominantly diagnosed with SJS (50%) or SJS–TEN overlap (33%). Time to healing among dressing-only subjects was not significantly different [12 (10–14.5) days] than among the Biobrane®-treated subjects, (p=0.127). ConclusionBiobrane® was applied to SJS–TEN subjects with more extensive epidermal detachment, had no significant complications, and generally facilitated epidermal healing in under 2 weeks from application.