The use of antioxidants in the treatment of Graves’ Disease: evaluating the results

Abstract

Topicality. Accelerated metabolism in Graves' disease causes the development of oxidative stress, which significantly affects the clinical course and treatment results. Purpose. This study was conducted to evaluate the effect of treatment with thyrosol and thyrosol in combination with antioxidants, in particular vitamins C and E, on indicators of thyroid hormone function (thyroid-stimulating hormone and thyroxine) and oxidative stress (malondialdehyde and total antioxidant capacity). Material and method. The clinical study was performed on 41 patients with newly diagnosed Graves' disease of moderate severity, aged from 21 to 43 years, who were divided into two groups. The control group consisted of 19 patients who received thyrosol for treatment. The main group included 22 patients who were treated with thyrosol in combination with vitamins C and E. Examinations were carried out upon inclusion in the program and one and two months after the start of treatment. Results. The conducted studies showed that in the course of treatment, the indicators of malic dialdehyde gradually decreased from 21.3±0.4 (17.3–29.2) to 10.31±0.1 (9.72–10.82) and thyroxine from 37.7±0.5 (31.2–42.7) to 15.31±0.2 (13.20–20.52) and the total antioxidant capacity increased from 0.69±0.04 (0.52–0.79) to 1.58±0.1 (1.48–1.61), thyroid- stimulating hormone from 0.01±0.004 (0.07–0.001) to 2.31±0.1 (0.90–3.52). These changes were more pronounced in the main group compared to the control group during the study one month and two months after the start of treatment. Conclusions. Thus, antioxidant supplements can be used to improve thyroid function in hyperthyroid patients by enhancing antioxidants and restoring the oxidant-antioxidant balance.