Abstract
Meeting abstracts Glioblastoma multiforme (GBM), is the most common adult brain tumor and despite many new therapies, remains largely incurable. Regulatory T cells (Treg) are highly immunosuppressive cells that accumulate within glioma microenvironment, and reduction of their function or
Highlights
Glioblastoma multiforme (GBM), is the most common adult brain tumor and despite many new therapies, remains largely incurable
We hypothesized that anti-GITR treatment suppresses granzyme expression by Tregs, which results in stronger anti-tumor immune responses against glioma
Mice received anti-GITR or its isotype control directly into the tumor site (2ug) or i.p. (500ug) at both 9 and 14 days post implantation Mice were separately assessed for survival, and flow cytometric analyses were performed to determine the influence of the antibody on immune response in the brain
Summary
Glioblastoma multiforme (GBM), is the most common adult brain tumor and despite many new therapies, remains largely incurable. The use of anti-GITR antibody treatment in a murine model of glioblastoma multiforme Regulatory T cells (Treg) are highly immunosuppressive cells that accumulate within glioma microenvironment, and reduction of their function or trafficking has been previously shown to enhance survival in pre-clinical models of GBM.
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