Abstract
Allogeneic freeze-dried skin has been used for many years in burn therapy. It can be stored indefinitely at room temperatures and is nonimmunogenic. It has potential use in the oral cavity where there is a limited supply of donor tissue or where the creation of a donor area wound is undesirable. Allogeneic freeze-dried skin was sutured into place over connective-tissue-bed recipient sites in the oral cavities of Macaca mulatta monkeys. Block sections were obtained at 0, 1, 4, 7, 21, 180, and 360 days. Clinical evaluation showed an enhanced uncomplicated healing sequence. Histologic examination revealed a biologic acceptance and incorporation of the collagen fibers of the graft tissue by the host, along with a postoperative reduction in inflammatory and osteoclastic response.
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