Abstract
In the last decade, adverse outcome pathways have been introduced in the fields of toxicology and risk assessment of chemicals as pragmatic tools with broad application potential. While their use in the pharmaceutical and cosmetics sectors has been well documented, their application in the food area remains largely unexplored. In this respect, an expert group of the International Life Sciences Institute Europe has recently explored the use of adverse outcome pathways in the safety evaluation of food additives. A key activity was the organization of a workshop, gathering delegates from the regulatory, industrial and academic areas, to discuss the potentials and challenges related to the application of adverse outcome pathways in the safety assessment of food additives. The present paper describes the outcome of this workshop followed by a number of critical considerations and perspectives defined by the International Life Sciences Institute Europe expert group.
Highlights
Toxicology, and chemical safety evaluation practice, have drastically changed over the past few decades
In 2017, this International Life Sciences Institute (ILSI) Europe task force established an expert group to explore the use of adverse outcome pathways (AOPs) in the safety evaluation of food additives
One of the key activities of this expert group was the organization of a workshop aimed at triggering an in-depth discussion on potentials and challenges related to the application of AOPs in the food industry
Summary
Toxicology, and chemical safety evaluation practice, have drastically changed over the past few decades. The present manuscript describes the major outcomes and recommendations from this workshop, and as such is a follow-up of a study of the ILSI expert group that characterized the coverage of critical effects relevant in the safety evaluation of food additives by AOPs (Kramer et al 2019).
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