THE USE OF A NEW APPROACH TO PREVENTION AND THERAPY OF ACUTE ARTERIAL HYPERTENSION WITH COMPLEX OF WELL-KNOWN DRUGS WITH VEGETABLE GLYCOSIDES (EXPERIMENTAL STUDY)

Abstract

Aim. To evaluate antihypertensive efficacy of nifedipine (N) and nifedipine complex (NC) in acute test in rats with adrenaline model of arterial hypertension. Material and methods. N is a conventional short acting formulation while NC is a new formulation of nifedipine in complex with glycyrrhizic acid. NC has an active substance 10 times less than N does in the same dose. Adrenaline which results in two times increase in blood pressure (BP) during 4 min was administered as a single i.v. dose (0,03 mg/kg) to normotensive unconscious male rats (body weight 190-220 g). NC and N were administered in the same dose (3,5 mg/kg) before and after adrenaline administration. Systolic BP recovering time was assessed. BP level was measured with direct method in carotid artery. Results. NC and N decreased in systolic BP in normotensive rats by 26 and 30% respectively. NC and N administered before adrenaline administration resulted in systolic BP recovering time reduction to 94,4 and 79,7 s respectively, which are less than this in control (204,8 s, р<0,001). Difference in time between NC and N is not significant (p<0,1). NC and N administered after adrenaline administration resulted in systolic BP recovering time reduction to 104,7 and 139 s respectively, which are also less than this in control (204,8 s, р<0,001). Difference in time between NC and N in this model is also not significant (p<0,1). Conclusion. NC with contents of active substance 10 times less than in N showed antihypertensive efficacy similar with this in N. NC can be used for prevention and therapy of acute arterial hypertension.