Abstract
Liver tissues in New Zealand rabbits were ablated using high intensity focused ultrasound (HIFU, 14 300 W/cm 2, 1.0 MHz). The animals were intravenously administered 0.2 ml of microbubble agent in the experimental ( n = 20) group and an isovolumetric normal saline solution in the control ( n = 27) group before HIFU treatment which was performed as a linear scan. In both groups, the preselected tissue volumes were destroyed without harming the overlying tissues. Necrosis rate (NR, cm 3/s) was used to reflect the ablation efficiency, which was the tissue volume of occurring coagulative necrosis per 1 s HIFU exposure. NR was improved in the experimental group (0.0570 ± 0.0433 vs 0.0120 ± 0.0122, P = 0.0002). Pathological studies confirmed that there were no residual intact targets within the exposed volume. These findings suggested that the introduction of the microbubble agent enhanced HIFU liver destruction.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.