Abstract
Home-use light-emitting diodes (LEDs) are attracting growing attention regarding their anti-aging effects. Although most previous studies on the use of LED devices as a form of low-level laser therapy reported no significant adverse events, questions regarding the safety of using a light source on secretory tissues have been raised. This study aimed to assess the safety and efficacy of a home-use LED device for neck skin rejuvenation, particularly regarding its effect on thyroid gland morphology and function. Thyroid function tests and ultrasonographic analyses showed no significant changes after 16 weeks of LED use. Evaluation using the Lemperle wrinkle scale and global improvement scales by both investigators and subjects showed significant improvement after 16 weeks of daily application, as well as 8 weeks after discontinuation. Biophysical parameters, such as hydration, elasticity, and density, also showed significant improvements. Hence, the long-term use of the LED device was safe and effective for neck rejuvenation, and showed no significant side effects on the adjacent thyroid and parathyroid glands.
Highlights
A light-emitting diode (LED) emits a narrow spectrum of non-coherent light in the near-infrared, visible, and ultraviolet (UV) ranges [1]
Out of the 39 patients who were screened, 30 adult women with clinically visible skin aging or wrinkles on the neck were deemed eligible for this study; those between the ages of 30–47 years with Fitzpatrick phototypes III to V were enrolled (Figure 3)
Red and near-infrared LEDs can be used as skin biostimulators to decelerate fibroblast aging by exerting antioxidative and collagen-enhancing activities [15,16]
Summary
A light-emitting diode (LED) emits a narrow spectrum of non-coherent light in the near-infrared, visible, and ultraviolet (UV) ranges [1]. LEDs are used for low-level light therapy (LLLT) and photodynamic therapy for various skin conditions [1]. The introduction of photobiomodulation, which includes low-energy laser treatment or LED phototherapy, has shown positive effects in skin rejuvenation [3]. Previous studies observed increased adenosine triphosphate production, modulation of intracellular oxidative stress, induction of transcription factors, and increased blood flow after LED phototherapy [4]. Li et al described the anti-inflammatory effect of a 630 nm LED via inhibition of reactive oxygen species and regulation of the nuclear factor-κB signaling pathway in human monocytes [5]. Park et al demonstrated increased synthesis of type 1 procollagen and decreased expression of matrix metalloproteinases (MMPs) 1 and 2 in skin fibroblasts after irradiation with a 633 nm LED, suggesting possible mechanisms underlying the effects of LED irradiation in anti-aging and skin rejuvenation [6]
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