Abstract
Abstract The aim of this work was to develop a cream formulation with potential antioxidant properties. Herein, a freeze-dried extract of Ligusticum mutellina was used as a source of active compounds. The proposed qualitative composition of the cream was characterized by a good polyphenolic compounds release profile. Of note, the highest R2adj values were obtained for the Korsmeyer-Peppas and Higuchi models (0.9159 and 0.9226, respectively). These results indicate that a freeze-dried extract of L. mutellina, due to its retained high phenolic acids content, could become a key component in antioxidant creams.
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