Abstract
The use of 18F-2-Fluoro-2-Desoxy-D-Glucose Positron Emission Tomography/Computed Tomography (FDG-PET/CT) has become an integral part of patient management in many lymphoid malignancies. However, the diagnostic accuracy of FDG-PET/CT in some indolent lymphoid malignancies with commonly low FDG-avidity, including Chronic Lymphocytic Leukaemia (CLL) can still be challenging in clinical routine [1-3,6,9]. CLL is defined as a low-grade proliferative B-cell proliferative disease often indolent, which can in about 5% of the cases turn into a more aggressive malignancy, most commonly into Diffuse Large B-Cell Lymphoma (DLBCL). This transformation is called Richter transformation, often detected too late and associated with a poor prognosis. Therefore, accurate imaging of CLL at an early stage could be useful for the management of the disease and improve patient’ssurvival [4,5,7,8,10].
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