The usage of melittin in breast cancer microenvironment targeting

Abstract

In today’s society, there are more people dying from breast cancer than ever. In fact, it has been projected that 1 in 39 women will die from breast cancer. Over the years, scientists have developed many forms of treatment to help alleviate some of the symptoms and keep the cancer at bay, such as chemotherapy and immunotherapy. Recently, however, a discovery has been made that could have the most efficacy and effectiveness against breast cancer. Melittin, a cationic peptide found in bee venom, is a 26 amino acid peptide that is being studied in many fields of medicine to be used as a new form of treatment in conjunction with the current forms. It is being tested in cancer research because of a special function that it has: the ability to start apoptosis by punching holes in the actual cell itself. In this paper, we will look at an overview of breast cancer’s history and statistics, look through some of the types of treatments that are already being used to fight breast cancer, and analyze five case studies to see how melittin can be used to target the microenvironments of breast cancer cells and figure out which method of treatment melittin will best fit into.