Abstract
BackgroundKashin-Beck disease (KBD) is an endemic osteoarthropathy, and its pathogenesis is still not entirely clear. Pathologically, many KBD changes are similar to those of osteoarthritis (OA). Therefore, this study aimed to identify changes in the levels of potential urinary biomarkers for OA, including C-telopeptide of type II collagen (uCTX-II), type II collagen cleavage neoepitope (uC2C), pyridinoline (uPYD), and uHelix-II, among adults with KBD.MethodsUrinary samples of 83 external control (EC) subjects, 91 KBD patients, and 86 internal control (IC) subjects were tested by ELISA after the subjects completed a questionnaire and X-ray examination.ResultsThe medians of the four markers in the KBD group were higher than those in the EC group and those in the IC group. The medians in the grade II KBD group were higher than those in the grade I group but were not statistically significant (P = 0.301, P = 0.408, P = 0.204, and P = 0.898 for uCTX-II, uC2C, uPYD, and uHelix-II, respectively). The area under the curve (AUC) of uCTX-II (0.775) was higher than that of the others (0.672, 0.639, and 0.628 for uC2C, uPYD, and uHelix-II, respectively).ConclusionThe levels of uCTX-II, uC2C, uPYD, and uHelix-II were elevated in adults with KBD and showed an increasing trend as the severity of KBD increased. The prediction accuracy of uCTX-II was more useful than that of the others for assisting in the diagnosis of KBD.
Highlights
Kashin-Beck disease (KBD) is an endemic osteoarthropathy, and its pathogenesis is still not entirely clear
The levels of uCTX-II, uC2C, uPYD, and uHelix-II were quantified by enzyme-linked immunosorbent assay (ELISA) in accordance with the manufacturer’s instructions
There were no differences between the internal control (IC) group and external control (EC) group (H = 1.490, P = 0.409; H = − 1.045, P = 0.889; H = − 1.659, P = 0.291; H = − 1.194, P = 0.698 for uCTX-II, uC2C, uPYD, and uHelix-II, respectively) (Fig. 1)
Summary
Kashin-Beck disease (KBD) is an endemic osteoarthropathy, and its pathogenesis is still not entirely clear. Many KBD changes are similar to those of osteoarthritis (OA). This study aimed to identify changes in the levels of potential urinary biomarkers for OA, including C-telopeptide of type II collagen (uCTX-II), type II collagen cleavage neoepitope (uC2C), pyridinoline (uPYD), and uHelix-II, among adults with KBD. Kashin-Beck disease (KBD) is an endemic osteoarthropathy [1], and its pathological characteristics are multiple symmetric degeneration or necrosis of articular cartilage and secondary osteoarthritis. KBD is a severe osteochondrosis (OC) with onset in childhood. Bone and cartilage destruction, matrix degradation, and other pathological changes caused by KBD are similar to those of osteoarthritis (OA), which has garnered widespread attention and been studied for a long time.
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